学习经历
2004-2008 河北农业大学，学士
2008-2011 兰州大学，有机化学硕士
2014-2019 清华大学，生物学博士
工作经历
2011-2012 重庆科学技术研究院生物医药研究中心
2012-2014 中国乐凯集团有限公司研究院
2019- 河北农业大学，校聘教授
教学工作
本科生课程：
1.基础课《药物化学》、《天然药物化学》
2.专业选修课《药物设计与合成》
主要研究方向及领域
1.基于生物活性导向的药物合成；
2.抗微生物药物的发现。
主持课题项目
1.国家自然科学基金，靶向胆固醇代谢途径抗流感抑制剂的发现及作用机制研究，2021-2024，22077026，主持
2.河北省自然科学基金，靶向人的类异戊二烯途径抑制剂影响流感病毒出芽的作用机制研究，2020-2022，H2020204002,主持
出版教材著作
代表性学术成果
研究论文（*通讯作者）：
1.Li Dong, Xiaoqing Wang, Gou Yanhui, Shuo Yu, Zhengsen Yu*, Photoredox/HAT-Catalyzed Intramolecular Hydrocyclization of Alkenes toward 2, 3-Fused Quinazolinones and Dihydroquinazolinones, Organic Letters, 2024, 26, 8756-8761.
2.Zhiyuan Bao, Yifei. Li, Ruitong Zhang, Zhengsen Yu, Chao Chen*, Electrophilic aryl spiroannulation induced by diaryliodonium salts: efficient synthesis of [5,5]-spiro lactone-lactam scaffolds from α-cyanocarboxylates, Green Synthesis and Catalysis, 2024.
3.Dong Li, Xiaoqing Wang, Yudi Nie, Shuo Yu, Haotong Li, Qian Zhao, Zhengsen Yu*, Regioselective Perfluoroalkylation of 4-Quinolones Using Sodium Perfluoroalkyl Sulfinates, European Journal of Organic Chemistry, 2022, 37, e202200842.
4.Fang Yang, Xiaoqing Wang, Wenzhuo Zhao, Fei Yu and Zhengsen Yu*, Hypervalent Iodine (III)-Promoted C3–H Regioselective Halogenation of 4-Quinolones under Mild Conditions, ACS omega, 2021, 6(49): 34044-34055.
5.Rong Xiang#, Zhengsen Yu#, Yang Wang#, Lili Wang, Shanshan Huo, Yanbai Li, Riying Liang, Qinghong Hao, Yaning Gao*, Fei Yu* and Shibo Jiang*, Recent Advances in Developing Small-molecule Inhibitors against SARS-CoV-2. Acta Pharmaceutica Sinica B, 2021, 12(4), 1591-1623.
6.Shuai Han, Xin Li, Xia Yun, Zhengsen Yu, Ningning Cai, Satich R. Malwal, Xu Han, Eric Oldfield*, Yonghui Zhang*, Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells, Journal of Medicinal Chemistry, 2019, 62 (23): 10867-10896.
7.Yun Xia#, Yonghua Xie#, Zhengsen Yu#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, and Yonghui Zhang*, The Mevalonate Pathway is a Druggable Target for Vaccine Adjuvant Discovery, Cell, 2018, 175 (4), 1059-1073.
发明专利：
于正森;王小清;孟许峰;汤建志;于硕;董力. C-3全氟烷基化4-喹啉酮类化合物的制备方法. ZL 2022 1 1133591.0, 2022-09-08.
